Ethical approval must be obtained before medical research can start. We describe the differences in EA for an pseudonymous, non-interventional, observational European study. Sixteen European national coordinators of the international study on very old intensive care patients answered an online questionnaire concerning their experience getting EA. N = 8/16 of the NCs could apply at one single national ethical committee, while the others had to apply to various regional ECs and/or individual hospital institutional research boards. The time between applying for (...) EA and the first decision varied between 7 days and 300 days. In 9/16 informed consent from the patient was not deemed necessary; in 7/16 informed consent was required from the patient or relatives. The upload of coded data to a central database required additional information in 14/16. In 4/16 the NCs had to ask separate approval to keep a subject identification code list to de-pseudonymize the patients if questions would occur. Only 2/16 of the NCs agreed that informed consent was necessary for this observational study. Overall, 6/16 of the NCs were satisfied with the entire process and 8/16 were unsatisfied. 11/16 would welcome a European central EC that would judge observational studies for all European countries. Variations in the process and prolonged time needed to get EA for observational studies hampers inclusion of patients in some European countries. This might have a negative influence on the external validity. Further harmonization of ethical approval process across Europe is welcomed for low-risk observational studies. Getting ethical approval for low-risk, non-interventional, observational studies varies enormously across European countries. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Reviewed by:Thomas Aquinas’s “Summa Theologiae”: A Guide and Commentary by Brian DaviesBrian J. Shanley, O.P.Thomas Aquinas’s “Summa Theologiae”: A Guide and Commentary. By Brian Davies, O.P. Oxford: Oxford University Press, 2014. Pp. xv + 454. $105.00 (cloth), $31.95 (paper). ISBN: 978-0-19-938062-6 (cloth), 978-0-19-938063-3 (paper).The purpose of this book is to provide guidance to a nonspecialist reader of Aquinas’s Summa theologiae. It is not meant as a substitute (...) for the text itself, but rather as a companion for a reader in order to offer explication for the most important arguments, a sense of the context of the whole, a quick survey of the terrain of a treatise, some historical context when necessary, and a prod to critical thinking. Davies’s ambition is daunting. As the subtitle indicates, he intends the book to be both a guide and a commentary. If it were only a guide, it would focus on the truly critical themes in some depth in order to aid the reader through the various parts without commenting on everything. If it were only a commentary, its purpose would be largely expository and exegetical. It is hard to do both functions well on a work as large and complex as the Summa theologiae.After a brief overview of Aquinas’s life and a short commentary on the meaning of sacra doctrina, Davies turns to the topic of God. Given his previous work on Aquinas, it is not surprising that the strongest and longest section of his book concerns the Prima pars. Davies does a nice job of parsing the existence of God and mapping out the Five Ways in a manner suitable to his audience. He then turns to the question of how God does not exist, and makes it plain that the main thrust of Aquinas’s treatment is apophatic, or negative. It is surprising that Davies never mentions the influence of Pseudo-Dionysius on Aquinas and generally downplays the Neoplatonic strains in Aquinas’s theology. I would have thought that divine simplicity and goodness deserve more consideration, and I would have liked to see Davies give more insight for the reader on how to parse some of Aquinas’s metaphysical terms (especially the real distinction in created beings and how this is the main marker of the ontological gap between God and creation). When Davies turns to how we name or use language about God, he signals to his readers that he is entering into an area that has been much debated. Not surprisingly, while he does a reasonable job of trying to explain how analogical predication works to a nonspecialist reader, specialists will have much to quibble about. At the heart of his explanation of analogy is the claim that analogy is primarily “a linguistic phenomenon in which one and the same word is used to speak of different things with connections of meaning that can be traced in each use of the word” (69). Analogy in Aquinas is more than a theory about language; it is embedded in a metaphysics of participation and creation that needs to be adumbrated to understand how analogy works. The subsequent treatment of God’s knowing and willing is reliable, though more attention might have been paid to the practical model of divine knowing. When it comes to the Trinity, [End Page 306] Davies does a solid job of trying to explain that most complicated doctrine of Aquinas to a nonspecialist.Davies misses the opportunity to explore the fundamental contrast that Aquinas draws between God’s causal immanence in all things as Creator and his special, interpersonal, Trinitarian indwelling through grace, as the treatise on the Trinity segues into the treatise on creation. When turning to creation, Davies notes that the fundamental metaphysical principle behind Aquinas’s account is that “the existence of something that does not exist by nature has to be caused” (110), although he seems diffident about its validity (“like it or not”) and never mentions participation. Sometimes he speaks about God’s causality in creation as “causally accounting for their esse” (ibid.) even as he notes that God... (shrink)

What makes an object the same persisting individual over time? Philosophers and psychologists have both grappled with this question, but from different perspectives—philosophers conceptually analyzing the criteria for object persistence, and psychologists exploring the mental mechanisms that lead us to experience the world in terms of persisting objects. It is striking that the same themes populate explorations of persistence in these two very different fields—e.g. the roles of spatiotemporal continuity, persistence through property change, and cohesion violations. Such similarities may reflect (...) an underlying connection, in that psychological mechanisms of object persistence (especially relevant parts of mid-level visual object processing) may serve to underlie the intuitions about persistence that fuel metaphysical theories. This would be a way for cognitive science to join these two disparate fields, helping to explain the possible origins and reliability of some metaphysical intuitions, and perhaps leading to philosophical progress. (shrink)

In three experiments, subjects attempted to track multiple items as they moved independently and unpredictably about a display. Performance was not impaired when the items were briefly (but completely) occluded at various times during their motion, suggesting that occlusion is taken into account when computing enduring perceptual objecthood. Unimpaired performance required the presence of accretion and deletion cues along fixed contours at the occluding boundaries. Performance was impaired when items were present on the visual field at the same times and (...) to the same degrees as in the occlusion conditions, but disappeared and reappeared in ways which did not implicate the presence of occluding surfaces (e.g. by imploding and exploding into and out of existence, instead of accreting and deleting along a fixed contour). Unimpaired performance did not require visible occluders (i.e. Michotte’s tunnel effect) or globally consistent occluder positions. We discuss implications of these results for theories of objecthood in visual attention. (shrink)

The notion that visual attention can operate over visual objects in addition to spatial locations has recently received much empirical support, but there has been relatively little empirical consideration of what can count as an `object' in the ®rst place. We have investi- gated this question in the context of the multiple object tracking paradigm, in which subjects must track a number of independently and unpredictably moving identical items in a ®eld of identical distractors. What types of feature clusters can (...) be tracked in this manner? In other words, what counts as an `object' in this task? We investigated this question with a technique we call target merging: we alter tracking displays so that distinct target and distractor loca- tions appear perceptually to be parts of the same object by merging pairs of items (one target with one distractor) in various ways ± for example, by connecting item locations with a simple line segment, by drawing the convex hull of the two items, and so forth. The data show that target merging makes the tracking task far more dif®cult to varying degrees depending on exactly how the items are merged. The effect is perceptually salient, involving in some conditions a total destruction of subjects' capacity to track multiple items. These studies provide strong evidence for the object-based nature of tracking, con®rming that in some contexts attention must be allocated to objects rather than arbitrary collections of features. In addition, the results begin to reveal the types of spatially organized scene components that can be independently attended as a function of properties such as connectedness, part struc- ture, and other types of perceptual grouping. q 2001 Elsevier Science B.V. All rights reserved. (shrink)

Some core knowledge may be rooted in – or even identical to – well-characterized mechanisms of mid-level visual perception and attention. In the decades since it was first proposed, this possibility has inspired (and has been supported by) several discoveries in both infant cognition and adult perception, but it also faces several challenges. To what degree does What Babies Know reflect how babies see and attend?

Trading on non-public material information is fertile ground for a discussion of ethical behavior. The long-running legal tug-of-war over what constitutes illegal insider trading delivers challenges to regulatory authorities charged with detecting and enforcing the law, and is likely one of the reasons that prosecution of insider trading events remains rather uncommon. One can observe both increased volume in the equity and option markets and run-ups in the stock price prior to the announcement of the acquisitions; however, the detection of (...) illegal or unethical insider trading can be difficult. Given the legal uncertainty around insider trading and the circumstantial evidence from the trading activity, it is almost impossible to identify unethical insider trades unless there is a whistleblower or trades are large in size and impeccable in timing. Using call option trading around two merger announcements with similar firms that resulted in different ultimate treatment from the SEC, we illustrate the struggle regulators and prosecutors have with identifying and enforcing unethical insider trades. (shrink)

How have figures of speech configured new concepts of time, space, and mind throughout history? Brian J. McVeigh answers this question in A Psychohistory of Metaphors: Envisioning Time, Space, and Self through the Centuries by exploring “meta-framing:” our ever-increasing capability to “step back” from the environment, search out its familiar features to explain the unfamiliar, and generate “as if” forms of knowledge and metaphors of location and vision. This book demonstrates how analogizing and abstracting have altered spatio-visual perceptions, expanding (...) our introspective capabilities and allowing us to adapt to changing social circumstances. (shrink)

We critically evaluate arguments in a recent Journal of Law, Medicine & Ethics article by Svoboda, Adler, and Van Howe disputing the 2012 affirmative infant male circumcision policy recommendations of the American Academy of Pediatrics. We provide detailed evidence in explaining why the extensive claims by these opponents are not supported by the current strong scientific evidence. We furthermore show why their legal and ethical arguments are contradicted by a reasonable interpretation of current U.S. and international law and ethics. After (...) all considerations are taken into account it would be logical to conclude that failure to recommend male circumcision early in infancy may be viewed as akin to failure to recommend childhood vaccination to parents. In each case, parental consent is required and the intervention is not compulsory. Our evaluation leads us to dismiss the arguments by Svoboda et al. Instead, based on the evidence, infant male circumcision is both ethical and lawful. (shrink)

This chapter explores a way in which visual processing may involve innate constraints and attempts to show how such processing overcomes one enduring challenge to nativism. In particular, many challenges to nativist theories in other areas of cognitive psychology have focused on the later development of such abilities, and have argued that such development is in conflict with innate origins. Innateness, in these contexts, is seen as antidevelopmental, associated instead with static processes and principles. In contrast, certain perceptual models demonstrate (...) how the very same mental processes can both be innately specified and yet develop richly in response to experience with the environment. This process is entirely unmysterious, as shown in certain formal theories of visual perception, including those that appeal to spontaneous endogenous stimulation and those based on Bayesian inference. (shrink)

The relations of comparison and contrast among the viewpoints of characters and between the viewpoints of authors and characters is one of the most important dimensions of meaning in literary texts.... It is for this reason that the analysis of irony, as a central tonal medium for registering differences in point of view, occupies a position of singular importance in the interpretation of literary meaning.Irony stings. Among friends it might be playful, its target joining in the fun. But it is (...) hard to see irony figuring into any how-to guide for making friends in the first place. Indeed, the word is absent from Dale Carnegie's How to Win Friends and Influence People. More often irony is divisive, driving a wedge... (shrink)

In this chapter I take up the question of how Aristotle understood the relationship between the contemplative life and the active life in contributing to human flourishing and to the political regime. While the connections between Aristotle’s ethics and politics are abundant, there exists a prevalent assumption in the inclusive/dominant debate concerning the interpretation of eudaimonia (human flourishing) that Aristotle’s Politics cannot or should not play a prominent role in helping to understand eudaimonia. On the ‘inclusivist’ reading, eudaimonia is understood (...) as being a composite of all human goods or virtues. On the ‘dominant’ reading, eudaimonia is understood as being a single dominant good, theōria (contemplation). With this chapter I offer a competing interpretation which is in some ways similar to the recent ‘all-inclusive’ reading, but which relies heavily on the connection between Aristotle’s ethics and politics in order to explain how theōria fits into humans’ composite and political nature. (shrink)

In Volume Two of Ernest Fortin: Collected Essays, Fortin deals with the relationship between religion and civil society in a Christian context: that of an essentially nonpolitical but by no means entirely otherwordly religion, many of whose teachings were thought to be fundamentally at odds with the duties of citizenship. Sections focus upon Augustine and Aquinas, on Christianity and politics; natural law, natural rights, and social justice; and Leo Strauss and the revival of classical political philosophy. Fortin's treatment of these (...) and related themes betrays a keen awareness of one of the significant intellectual events of our time: the recovery of political philosophy as a legitimate academic discipline. (shrink)

Such a moral theology not only provides us with a convincing certainty of God's being, but it also has the great advantage that it leads us to religion, since it joins the thought of God firmly to our morality, and in this way it even makes better men of us. Kant, Lectures on Philosophical TheologyThis philosophy too, which takes up the thought of confederation in the concept of communicative, historically situated reason, will be able to provide no assurance (keine Zuversicht); (...) it stands in the sign of a transcendence from within and must content itself with the justified encouragement of a skeptical but non-defeatist “resistance to the gods and demons of a world contemptuous of man.” Habermas, “Israel oder Athen: Wem gehoert die anamnetische Vernunft?”. (shrink)

The ascendancy of aesthetics as a philosophical discipline / Daniel Dahlstrom -- Western philosophy of religion in the last hundred years / Eugene Thomas Long -- Western challenge to the development of the history of Chinese philosophy / A.S. Cua.

Some of the evidence for a “magical number 4” has come from the study of visual cognition, and Cowan reinterprets such evidence in terms of a single general limit on memory and attention. We evaluate this evidence, including some studies not mentioned by Cowan, and argue that limitations in visual processing are distinct from those involved in other memory phenomena.

Renin is the rate‐limiting enzyme in a cascade that leads to production of angiotensin II, which is perhaps our most important regulator of salt and water balance and blood pressure. In this personal perspective, I describe how I entered the renin field 33 years ago by discovering that proteases increased the level of renin activity in biological fluids, so revealing the existence of a ‘pro’ form of the molecule. This led me on a journey that encapsulated all of the major (...) milestones in molecular discovery for renin. These included (1) the elucidation of the steps in renin biosynthesis, (2) the cloning of renin cDNA and its gene, (3) demonstration of the structure of the renin protein, (4) using the renin gene in the first genetic studies in hypertension, (5) finding the mechanism by which the major controller, cyclic AMP, regulates the promoter, (6) showing that a strong enhancer and its weak promoter control this physiologically regulatable gene in accord with the variegation (on/off switching) model, and (7) being the first to identify molecules involved in posttranscriptional control. The renin molecule, its gene and molecular control are now very well understood, but more fine details on the topic of renin continue to emerge to delight ‘reninologists’ and others. BioEssays 25:520–527, 2003. © 2003 Wiley Periodicals, Inc. (shrink)

This handbook provides an overview of the research on the changing nature of work and workers by marshalling interdisciplinary research to summarize the empirical evidence and provide documentation of what has actually changed. Connections are explored between the changing nature of work and macro-level trends in technological change, income inequality, global labor markets, labor unions, organizational forms, and skill polarization, among others. This edited volume also reviews evidence for changes in workers, including generational change, that has accumulated across domains. Based (...) on documented changes in work and worker behavior, the handbook derives implications for a range of management functions, such as selection, performance management, leadership, workplace ethics, and employee well-being. This evaluation of the extent of changes and their impact gives guidance on what best practices should be put in place to harness these developments to achieve success. (shrink)

Prior to its publication, Gary Cox's MakingVotesCount was widely and eagerly anticipated. (Indeed, some years ago, I received a referee report dismissing my submission as unnecessary because superior analysis would eventually appear in Cox's then forthcoming manuscript.) Upon its release in 1998, the book was instantly lauded: it collected multiple awards, including the prestigious Woodrow Wilson prize for best book published on government, politics, or international affairs. This acclaim was scarcely surprising – Cox has been one of the foremost scholars (...) of elections and legislatures for the whole of his professional career. He is responsible for an impressive body of work spanning multiple research topics, nations, and methods of analysis. This book is testimony to his breadth, as it catalogs the key electoral features of virtually the whole set of modern democracies (more than 70), and makes frequent forays into diverse nations in search of empirical support for novel theoretical findings. In brief, Cox's project is to bring together a large formal, deductive literature on voting rules and social choice with an equally voluminous empirical, inductive literature on elections and party systems in the world's democracies. The prizes it garnered are one measure of the book's success at this merger; a large boost in Cox's swelling citation count will doubtless follow, reiterating the judgement that this is the major work on electoral law and voting to date. (shrink)

We suggest that the sensorimotor “theory” of vision is really an unstructured collection of separate ideas, and that much of the evidence cited in its favor at best supports only a subset of these ideas. As an example, we note that work on change blindness does not “vindicate” (or even speak to) much of the sensorimotor framework. Moreover, the ideas themselves are not always internally consistent. Finally, the proposed framework draws on ideas initially espoused by James Gibson, but does little (...) to differentiate itself from those earlier views. For even part of this framework to become testable, it must specify which sources of evidence can support or contradict each of the component hypotheses. (shrink)

Is innate cognitive modularity consistent with a lack of innate neural modularity? Quartz & Sejnowski's implicit negative answer to his question fuels their antinativist and antimodular cognitive conclusions. I attempt here to suggest a positive answer and to solicit discussion of this crucial issue.